Our UK DRI Partnership Showcase – An Early Career Researcher’s Perspective

21st July 2020 by Nonye Nwuke

Written by Nonye Nwuke, DEMON Network Research Assistant

On the 17th July 2020, the DEMON Network collaborated with the UK Dementia Research Institute (DRI) for its inaugural partnership Research Showcase. The event highlighted the strength of the UK DRI and DEMON Network to bring together experts in different fields, showcasing the opportunities for knowledge exchange and collaboration to drive forward experimental dementia research.

“I was impressed by the ability of the speakers to communicate their findings in an accessible way”

As an undergraduate pursuing a career in the sciences, I had limited knowledge regarding data science and its ability to transform dementia research. Upon attending, I was impressed by the ability of the speakers to communicate their findings in an accessible way whilst also relaying the importance of their individual themes to advancing dementia research.

Dr Michele Veldsman’s talk on MRI markers of cerebrovascular cognitive impairment introduced the importance of openly available datasets like the UK Biobank as powerful resources. I was able to grasp the advantages of working with large data sets through her research findings, such as the ability to deduce patterns in data which may not be otherwise seen in smaller cohorts. Michelle’s data-driven approach to research was unlike what I have encountered throughout my studies, and I am intrigued to learn more about this in the future.

“this event provided me with valuable insight into the variety of themes underlying dementia research“

The research presented by Dr Nathan Skene also reinforced the importance of data-driven approaches. He discussed using large data sets, focusing on the use of genetics to determine underlying mechanisms behind brain disorders. I had come across RNA sequencing when studying the Principles of Medical Research module at university. However, it was interesting to note how this could be practically applied within academic research.

Finally, Professor Graham Ball discussed machine learning for biomarker discovery, pathway modelling and potential causality determination in Alzheimer’s disease. Despite being least familiar with machine learning and bioinformatics, I found the talk engaging. I particularly appreciated learning how these complex pathway models were created and interpreted.

To conclude, this event provided me with valuable insight into the variety of themes underlying dementia research. With future collaborative initiatives on the agenda, the DEMON Network and UK DRI have taken the first steps to ensure real-world impact!