UK Biobank Special Interest Group launched

UK Biobank has been identified as a key Network resource, and many of our members have experience in using this data for dementia-related analyses. To help develop resources and facilitate further collaborative analyses, papers and grants we’ve formed a dedicated Special Interest Group (SIG) with it’s own Slack channel. All members of the DEMON Network are invited to join the UK Biobank SIG if they’re interested in this study, and prior experience is not needed to join. The SIG is led by Prof David Llewellyn (DEMON Network Director) and Dr Janice Ranson (DEMON Network Deputy Director) who are both actively using UK Biobank data.

“We cannot afford to work in silos on ‘narrow’ problems in traditional ways. DEMON Network members are innovators keen to learn from each other, pool resources and experiment. I look forward to working on ambitious projects using UK Biobank data in new and creative ways.” Prof David Llewellyn

Many of our enterprising members have already published high profile papers incorporating genetics, imaging, lifestyle, clinical factors, and biomarkers. Our new UK Biobank Special Interest Group will help to drive forward advances in our understanding of dementia diagnostics, potential treatments and prevention.

Selected UK Biobank publications featuring DEMON Network members:

Nevado-Holgado, A.J., et al. (2016). Commonly prescribed drugs associate with cognitive function: a cross-sectional study in UK Biobank. BMJ Open, 6(11), e012177.

Zhou, A., et al., (2018). Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific Reports, 8(1), 7526.

Cullen, B., et al. (2018). Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Scientific Reports, 8, 12089.

Lourida, I., et al. (2019). Association of Lifestyle and Genetic Risk With Incidence of Dementia. Journal of the American Medical Association, 322(5), 430-437.

Petermann-Rocha, F., et al. (2020). Associations between physical frailty and dementia incidence: a prospective study from UK Biobank. The Lancet Healthy Longevity, 1(2), e58-e68.

Veldsman, M., et al. (2020). Spatial distribution and cognitive impact of cerebrovascular risk-related white matter hyperintensities. Neuroimage: Clinical, 28, 102405.

Veldsman, M., et al. (2020). Cerebrovascular risk factors impact frontotemporal network integrity and executive function in healthy ageing. Nature Communications, 11, 4340.

Veldsman, M., et al. (2021). The human hippocampus and its subfield volumes across age, sex and APOE e4 status. Brain Communications, 3(1), fcaa219.

Garfield, V., et al. (in press). HbA1c and brain health across the entire glycaemic spectrum. Diabetes, Obesity and Metabolism.

Spoviero, W., et al. (in press). High blood pressure and risk of dementia: a two-sample Mendelian randomization study in the UK Biobank. Biological Psychiatry.

Cho, B.P.H., et al. (in press). NOTCH3 variants are common in the general population and associated with stroke and vascular dementia: an analysis of 200,000 participants. Journal of Neurology, Neurosurgery & Psychiatry.

Anaturk, M., et al. (preprint). Development and validaton of a novel dementia risk score in the UK Biobank cohort. PsyArXiv Preprints.

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